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Paudel et al., 2018

Retatrutide's half-life of approximately 6 days supports this weekly schedule

Many peoples natural GLP-1 signal just isnt strong enough to keep cravings and blood sugar in check

Impact in Type 2 Diabetes In individuals with type 2 diabetes, Retatrutide also improved glycemic control, though weight loss outcomes were slightly less dramatic compared to non-diabetic participants

By contrast, treatment of high-risk diabetic patients with GLP-1R agonists such as lixisenatide and exenatide, which are based on the structure of nonhuman exendin 4, has not resulted in consistent reductions in MACEs (17, 18)

Importantly, improvements in blood glucose often begin before substantial weight loss occurs, suggesting that GLP-1 medications exert direct metabolic effects in addition to their impact on body weight