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Vitrified specimens and data collection Holey TEM grids (Ultrafoil R1.2/1.3 Au 300 gold foil grids, Quantifoil GmbH) were pre-washed with chloroform prior to glow discharged

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Considering the well-documented gonadotoxicity of platinum-based chemotherapeutics and the growing evidence supporting the antioxidative and anti-inflammatory properties of MEL and GSH, this study aims to explore a novel therapeutic strategy to mitigate chemotherapy-related ovarian toxicity

The majority of the mitochondrial pool of folate is THF and 10-formyl-THF with less than 10% being 5-methyl-THF and 5-formyl-THF

Oxidative stress is a key contributor to aging and various chronic diseases, including cancer, diabetes, and neurodegenerative disorders

Each patient receives an assessment to determine the correct approach