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doi: 10.1007/BF01705539 44 MakowskiL.NolandR

The discrepancies of GLP-1 in these studies definitely depend on the model (in vivo/in vitro), species, and the duration of GLP-1 (short/sustained half life)

Despite the relatively short half-life, clinical effects can persist for several hours to days after administration, suggesting that pharmacodynamic effects outlast plasma drug levels through persistent changes in neural circuit activity initiated by melanocortin receptor activation

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Evolutionary Implications of Sequence Structure Compatibility in Groups of Homologous Proteins

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