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179 Although the evidence is inconclusive, some research suggests oral systemic DHEA may improve cognitive function, mood, and sexual function in healthy older individuals, and may help mitigate bone loss, loss of muscle mass and strength, and the increase in abdominal fat that occurs in aging women

Nuclear and mitochondrial area were calculated using the Analyze particle function in Fiji

For the subgroup analysis, the studies were classified based on if the patients from the control group received metformin or placebo

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Timing is one key element

Newer diabetes medications like GLP-1 receptor agonists (Ozempic, Mounjaro) seem to promote the most weight loss, while oral drugs like metformin and SGLT2 Inhibitors (Jardiance) tend to lead to more modest outcomes for weight