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Deamidation converts asparagine residues to aspartate through a reaction with water, altering the peptide structure and reducing receptor binding affinity

Over the subsequent 48 weeks, participants who continued semaglutide experienced an additional mean weight loss of 7.9%, whereas those switched to placebo regained 6.9% of body weight, resulting in a significant 14.8 percentage-point treatment difference

doi: 10.3389/fphar.2022.977062 9 MaGZhangZLiPZhangZZengMLiangZet al

Some women taking semaglutide have reported more regular menstrual periods