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The enhanced permeation and retention (EPR) effect enables passive targeting through leaky vasculature, while active targeting utilizes antibody or peptide recognition systems

This does not make it the most effective, which remains debated, but it does make it among the best characterized for safety

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these effects were reversed after the overexpression of ILF3 (Fig

Globally, CKD affects 8 to 16% of the population [2], and is very closely associated with adverse clinical outcomes and an increased risk of all-cause mortality [3]

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