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Eli Lilly's Zepbound delivered up to 22% weight loss after 72 weeks, while Novo Nordisk's Wegovy has led to 15% weight loss after 68 weeks.

The neuron-specific deletion of SOCS3 increases leptin sensitivity through STAT3 activation, indicating that SOCS3 is an important negative feedback regulator of leptin signaling [99, 100]

Forecasting Framework and Scenario Modelling Market forecasts were developed using a combination of time-series modelling, adoption curve analysis, and driver-based forecasting tools

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Independent of Weight Loss (Humans) While weight loss plays a key role in improving pulmonary outcomes with GLP-1RAs, recent studies that account for BMI suggest that the benefits extend beyond metabolic changes

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