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In March 2024, Regor Therapeutics Group, a clinical-stage global biopharmaceutical company utilizing a cutting-edge drug discovery engine and a differentiated clinical development pipeline, announced the initiation of its Phase 2 trial of the highly selective oral GLP-1 agonist RGT-075

Preclinical research cell experiments: In the laboratory, the synthesized semaglutide is cultured together with cell lines expressing GLP-1 receptors

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Using a PTOA mouse model, Knights and colleagues revealed that the Wnt/-catenin signaling agonist Rspo2 was strongly upregulated after injury and exclusively secreted by Prg4 + lining layer FLS (73)