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59 Recently, the SURMOUNT-5 trial demonstrated that tirzepatide was superior to semaglutide in obese patients without diabetes with respect to reductions in body weight and waist circumference at week 72

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Vagal afferent neurons are necessary for hypolocomotion in ABX mice To identify the neurons that are activated in ABX mice after OFT exposure, we analyzed the expression of c-Fos, a transcription factor associated with neuronal activity in a time dependent manner 45,46 , in the brains of SPF and ABX mice 80 min after OFT (Fig