The SURMOUNT-1 trial [29] studied the effects of tirzepatide on body weight in those who are overweight or obese by monitoring the change in baseline body weight, TAG, high-density lipoprotein, very-low-density lipoprotein, free fatty acids, etc
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Although preclinical and clinical data are promising, the detailed molecular mechanisms by which tirzepatide influences MAFLD remain unclear
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Clinical teams recognized that synthetic versions of GLP-1 could address multiple metabolic problems simultaneously: blood sugar control, reduced appetite, and slower digestion