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In the obese state, EAT expansion induces a pro-inflammatory and pro-oxidative cardiac microenvironment, promotes ectopic infiltration of cardiomyocytes, and thereby contributes to the development of insulin resistance, endothelial dysfunction, mitochondrial dysfunction, and myocardial fibrosis (63)

[DOI] [PubMed] [Google Scholar] 58.Nikkola J, Laukkarinen J, Lahtela J, Seppnen H, Jrvinen S, Nordback I, Sand J

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Due to which patients even stop taking their medication entirely at times

In March 2026, Lilly also reported positive Phase 3 data for retatrutide in type 2 diabetes

Methylene blue should not be used in combination with certain psychiatric serotonin medications, during pregnancy or nursing or severe liver and kidney disease