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Data availability All the data and material were available

Ethics approval and consent to participate All relevant ethics documents were approved by the Institutional Research Ethics Committee of Nanjing Medical University (for clinical patients) and Nanjing University (for mice)

Oral bioavailability of GLP-1RAs with permeation enhancers in vivo Male Sprague Dawley rats (Charles River, Shrewsbury, MA, USA) weighing 250275 g were housed with ad libitum access to standard chow and water

BPC-157 and TB-500 are listed as prohibited substances under WADA and USADA

Nutritional support No nutrition guidance, meal plans, or dietary resources are included

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