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Because vitamin B12 is important for maintaining your energy levels, some people promote taking high doses of vitamin B12, far beyond the recommended dose, to improve their health

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E., & Zolotarev, Y

10.1093/nutrit/nuac110 49

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Additionally, low laminar flow found in smaller vessels promotes a quiescent state in ECs, while in larger vessels, higher physiological shear stress induces ECs' elongation and alignment parallel to the flow direction [208, 209]