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Monotherapy with semaglutide alone may be appropriate for newly diagnosed patients with mild hyperglycemia, those with severe metformin intolerance, or patients with eGFR below 15 mL/min/1.73m where metformin is contraindicated

However, with rapid results can come an unexpected side effect: the Ozempic facea term used to describe the hollowed, sagging appearance that some patients experience as their facial fat rapidly disappears

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A common benchmark is the Mifflin-St Jeor equation, which estimates your resting metabolic rate, then multiplies it by an activity factor (typically 1.2 to 1.5 for light to moderate exercise)