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A total of 42 genes related to GLP-1 signaling were obtained from Gene Set Enrichment Analysis (GSEA) Molecular Signatures Database ( and the protein-protein interaction network of the genes was analyzed in STRING database ( (Supplementary Figure S1)

21 The introduction of Aib 2 into GIP has also been reported, and it seems that it does not obviously affect the cAMP activity

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Philp et al

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The prevalence of adult obesity has more than doubled, while adolescent obesity has seen a fourfold increase