glp 1 agonist moa Mechanisms of action of GLP-1RA Mechanism of Action of GLP-1

2023 Feb 1;296:115548 :

The CAPTAIN trials used 50 mL daily for acute treatment and 10 mL daily for maintenance

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Subsequent work has reported that the spinogenic effect requires HGF/c-Met activation and is blocked by the same Hinge antagonist that blocks the procognitive effect in vivo [3]