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Cloudiness indicates bacterial contamination or particulate formation, both of which make the solution unsafe for injection

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(2) ROS activates NF-B and MAPK signaling pathways, upregulating the expression of MMPs (MMP-13, MMP-3) and inflammatory factors (IL-1, TNF- ), thereby accelerating the degradation of type II collagen (Col-II) and proteoglycans

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dermatologist 57: 1143-1153 Tio D et al (2018) Variation in the diagnosis and clinical management of lentigo maligna acrossEurope : a survey study among European Association of Dermatologists andVenereologists members.J Eur Acad Dermatol Venereol 32:1476-1484