This is the body adjusting to GLP-1 and GIP receptor activation, particularly the slowed gastric emptying that GLP-1 produces
When you eat, nutrientsparticularly carbohydrates, fats, and proteinsstimulate these L-cells to release GLP-1 into the bloodstream
Healthcare professionals should provide comprehensive patient education at treatment initiation, including written instructions and, where possible, practical demonstration
GLP-1 receptor signaling in pancreatic alpha cells reduces glucagon secretion, further contributing to glucose lowering
Licensed options in the UK include orlistat (oral), semaglutide 2.4 mg (Wegovy, approved by NICE TA875 for eligible patients), and tirzepatide (Mounjaro for type 2 diabetes
12 Another limitation is the variability of the available literature, which includes different research designs (RCTs, cohorts, casecontrol studies)