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They work differently and carry different risk profiles

Popovich IG, Voitenkov BO, Anisimov VN, Ivanov VT, Mikhaleva II, Zabezhinski MA, Alimova IN, Baturin DA, Zavarzina NY, Rosenfeld SV, Semenchenko AV, Yashin AI

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Remove once it becomes translucent for enhanced effectiveness

And the state of the medication, whether it is an unopened pen, an opened vial, a lyophilized powder , or a reconstituted solution , dramatically changes the storage requirements

PLoS ONE 1 , e116 (2006)