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During 72 weeks of treatment, people taking tirzepatide at doses of 5, 10, or 15 mg lost an average of 15.0%, 19.5%, and 20.9%, respectively, compared with just 3.1% in people taking a placebo

The result is a molecule that activates the same receptor as GLP-1, but stays active far longer

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Choosing between a medication that increases heart rate and blood pressure versus one that reduces MACE events by 20 percent is not a close call when cardiovascular health is a concern

Metabolic Brain Disease, 38(1), 25-34

Porter et al., 2013)