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Inflammatory cytokines IL-1 and IL-18 present in the ovarian tissue and FF in PCOS patients alter the follicular microenvironment by binding to receptors like IL-1R and TLR4 on the GCs, activating NF-B, which subsequently translocates into the nucleus (50)

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A.RebezovM.et al (2021)

London: IntechOpen

Berberine is a plant extract shown in studies to lower blood sugar levels and improve metabolism