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The accumulation of amphetamines effectively reverses the transporter carrier mechanisms, leading to a massive, non-exocytotic efflux of vesicular dopamine out into the cytosol, where it is subsequently transported into the synaptic cleft (Wimalasena 2011)(see Figure 2 Mechanism B)

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This oncogenic reprogramming extends to miRNA dysregulation: LMF exposure markedly upregulates three critical oncogenic miRNAs (miR-155, miR-21, miR-210) while suppressing two tumor-suppressive miRNAs (miR-126, miR-200c), thereby promoting a metastatic profile

Piwecka et al., 2023

Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus