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People who cannot absorb B 12 need regular injections

A deficiency of vitamin B12, therefore, results in reduced production and maturation of cells with high turnover particularly red blood cells

When Selectivity Matters Most: The selective action of AOD-9604 is particularly valuable for individuals with insulin resistance, pre-diabetes, or type 2 diabetes who cannot tolerate glucose elevation, those with personal or family history of cancer who wish to avoid IGF-1 elevation, people seeking pure fat loss without muscle gain or other body composition changes, athletes who need fat loss without anabolic effects or hormonal changes that might affect testing, individuals on complex medication regimens where growth hormones effects would require dose adjustments, and those who prefer targeted interventions over systemic hormonal therapy

Any discussion of interactions at this stage is therefore based on pharmacological reasoning and extrapolation from related, licensed GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy) and tirzepatide

Response: We thank the commenters for their support and for noting the importance of engaging patients and caregivers for information on the effectiveness of communication of information related to their care

171 The development of small molecule GLP-1RAs aims to overcome some of the limitations of traditional protein or peptide-based GLP-1RAs, such as the need for injection