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The pars superficialis on the lateral lip alters the direction of this muscle to run almost vertically in the area below the ala, leading to aberrant attachments to the nostril and periosteum of the piriform aperture

The cumulative effect builds over 2 to 4 weeks of consistent injections, which is why Triny typically recommends a loading phase before transitioning to monthly maintenance

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Human genetic studies have also linked IDE to AD [6], [7], [8]