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Combination therapy has shown somewhat higher rates of GI events compared to either monotherapy, and slow, gradual dose titration significantly improves tolerability

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PEGylation, for instance, makes medications stay in the body longer, but it can also make the body generate anti-PEG antibodies after a few doses

"Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa." Bulletin of Experimental Biology and Medicine

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Its also referred to as cows milk protein intolerance, and its different than a milk allergy