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In theory, random distribution should preferentially engage cross-reactive B cells that can cross-recognize multiple versions of RBD/spike proteins next to each other on the nanoparticle

One must decipher mode(s) of action at the cellular and molecular levels (most natural products exert antioxidant activities that have strong inflammatory/anti-inflammatory potential)

The integration of nanotechnology into this field has further advanced the potential of these compounds by enabling the creation of smart nanomaterials that improve solubility, bioavailability, and metabolic stability (118)

Acknowledgement The authors are thankful to Rangsit University and National Research Council of Thailand (NRCT) for supporting and funding this project

[DOI] [PubMed] [Google Scholar] Gartenhaus RB, Prachand SN, et al

Have you tried any of these, if so what are your thoughts