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Nutrition and Metabolism 13, 92
Given that infusions of GLP-1(2836) and GLP-1 have been shown to influence body weight and blood glucose levels in high-fat dietfed mice (24) and that we ourselves have documented an effect of calorie restriction and weight loss on cardioprotection (25), we examined the consequence of our 14-day infusions on these parameters
The EM structures (Figure 2b) of the receptor revealed that it is composed of: The extracellular domain (E) of the GLP-1 receptor binds the GLP-1 protein A seven transmembrane helical domain (TM1-7) with the -helices separated by three intracellular loops (IC1-3) and three extracellular loops (EC1-3) An intracellular (Cytoplasmic) C-terminus that interacts with G-Protein which is responsible for signaling The extracellular domain: The N-terminal ~120 amino acids of the extracellular domain of the GLP-1R protein has one long and one short helix, two beta strands forming a sheet and several loops joining these secondary structural elements