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In adipocytes, NNMT inhibition elevates NAD and SAM and suppresses de novo lipogenesis in a concentration-dependent manner, consistent with on-target activity [13]

Although growing evidence highlights the impact of choline metabolism on macrophages and microglia, there is a knowledge gap regarding its effects on other tissue-resident immune sentinels, such as Kupffer and Langerhans cells

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Mechanisms of ADA Formation ADAs are typically formed when the immune system recognizes the receptor agonists as a foreign entity