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Upon binding to AREs in the nucleus, NRF2 interacts with other co-activators, such as the CBP/p300 protein, forming a complex that further activates the transcription of antioxidant and detoxification genes [30]

Caffeine inhibits the activation of hepatic stellate cells induced by acetaldehyde via adenosine A2A receptor mediated by the cAMP/PKA/SRC/ERK1/2/P38 MAPK signal pathway

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Legrand O, Perrot JY, Tang R, Simonin G, Gurbuxani S, Zittoun R, Marie JP

Such changes predominantly encompass amplifications and deep deletions, implying pivotal roles for MTs in the context of cancers