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the first step is conjugation of glutamic acid and cysteine, which is catalyzed by glutamate-cysteine ligase and generates -glutamyl-cysteine (-Glu-Cys) and the second step is catalyzed by glutathione synthase, which adds glycine to -Glu-Cys, forming glutathione

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Moreover, we observed that APAP also leads to severe growth arrest in vitro, with a little detectable proliferation from 2 mM APAP upwards (Fig

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Therapeutic diets are formulated based on current research into the effect of dietary ingredients or nutrient compositions that may affect disease progression