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With regard to catalytic mechanism, all the seleno-GPxs share the common pathway which starts with the binding of hydroperoxides and GSH at the catalytic and thiol binding motifs, respectively [8, 11,12,13,14,15,16,17,18]

Mutations in genes like CHRNA4 (encoding the alpha-4 nicotinic acetylcholine receptor subunit) have been associated with altered cholinergic signaling, potentially contributing to cognitive decline in Alzheimer's disease

although, inter-patient variability in pharmacokinetic parameters was high

Alcohol can interfere with treatment effectiveness, worsen gastrointestinal side effects, and pose specific risks for patients with diabetes

In men, visceral fat is linked with lower testosterone levels, which can affect energy, muscle mass, and sexual health

As is a naturally occurring poison universally present in the Earth's crust, and is used in antifungal wood preservation processes, as an element of industrial manufacture, pesticides, and fireworks materials (Figure 2) [24]