Many studies rely on animal models or small human cohorts, which may not fully represent the complexity of human microbiota interactions
Also, could you let me know if it has any side effects
Depending on the genetic background of the animals, up to 15% of IGF-I knockouts survive to adulthood but are infertile and growth retarded (Baker et al ., 1993)
We previously demonstrated that growth attenuation of rv1127c in propionate is rescued by the addition of either vitamin B 12 or acetate (Basu et al, 2018), data that phenocopies Mtb mutants lacking MCC enzymes (Lee et al, 2013), thus supporting an unexpected role for Rv1127c in the MCC (Borah et al, 2021)
10.1556/APhysiol.87.2000.3.5
It also inhibited tumor development in other parts of the intestine (6)