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Upregulated: collagen, elastin, stem cell activation, DNA repair, and antioxidant genes Downregulated: inflammation, tissue breakdown, and cellular aging pathways In a landmark 2018 study, fibroblasts treated with GHK-Cu showed genetic signatures identical to younger cells with increased DNA repair enzymes, normalized oxidative stress markers, and restored mitochondrial function

(15) GHRP-2 Peptide and Inflammation To further elucidate the potential action of GHRP-2 on oxidative stress and inflammation, a study on murine models with artificially induced acute lung injury suggested that exposure to GHRP-2 may reduce lung edema, neutrophil infiltration, and levels of pro-inflammatory cytokines

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This potential has been evaluated in cell growth studies, throughout which researchers first prompted the need for developing this high-potency variant