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This review integrates current mechanistic insights with orthopaedic relevance, emphasizing safety, efficacy, and future directions for responsible integration into musculoskeletal care

Manufactured under controlled conditions, it is intended for analytical and laboratory research applications involving peptide-based experimental systems

Despite the absence of inflammation, the immune system constantly modulates and exerts pressure on gut microbiota

Currently, no FDA-approved sermorelin products are marketed in the US, and it is typically accessed through compounding pharmacies

It has not been established through a controlled in-vivo human trial

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