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Decreased postmeal insulin clearance Peripheral insulin concentrations are determined by the balance between insulin secretion and (mainly hepatic) insulin clearance

doi: 10.1056/nejmoa2206038

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Used together, their combined effect on neuroinflammatory tone may be more comprehensive than either achieves alone, helping to slow the inflammatory processes that accelerate neurodegeneration during and after the menopausal transition

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Lancet 400(10366):18691881 Jastreboff AM, Kaplan LM, Fras JP, Wu Q, Du Y, Gurbuz S et al (2023) Retatrutide phase 2 obesity trial investigators