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Peripherally, these agents induce significant weight loss, enhance insulin sensitivity, and reduce hepatic de novo lipogenesis

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At the drug concentrations produced by weekly dosing, the natural peak-and-trough cycle allows partial receptor resensitization during the trough period

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Research suggests that muscle lossas indicated by decreases in fat-free mass (which includes muscle as well as bones, water, and organs)with the medications ranges from 25% to 39% of total weight loss throughout 36 to 72 weeks, according to a 2024 study