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Yang XD et al

It is caused by a mutation in the huntingtin gene (HTT), which causes an expansion of a glutamine-containing repeat sequence (polyQ) beyond 36 repeats

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This proposed mechanism has been directly validated in animal models where the surgically severed vagus nerve attenuated anxiety- and depression-like behaviors in mice after oral antibiotic administration, providing direct evidence for neuropsychiatric effects induced by antibiotics through the gutbrain axis (Joo et al., 2023)