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There are a few contraindications: People with family history of medullary thyroid cancer or a rare genetic syndrome called MEN2 should not take GLP-1s, for instance

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The metabolic benefits are practice-changing

GIPR internalization is mainly influenced by -arrestin 2

By reducing appetite and cravings, it allows you to make dietary changes that may have felt impossible before

Additionally, it enhances insulin secretion in response to meals while suppressing glucagon release, which helps regulate blood sugar levels and may indirectly support weight management