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In dextran sulphate sodium (DSS)-induced colitis mice, the most commonly used preclinical IBD model, injected MOTS-c significantly reduced colon shortening and histological damage, lowered pro-inflammatory cytokines and plasma myeloperoxidase, and curbed macrophage and neutrophil activity

Glutathione transferase activity decreased in rheumatoid arthritis, which can be related to shortness of reduced glutathione developing during oxidative stress

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Our guide to vitamin C oxidisation is here to help, but a great place to start to gauge the lifespan and efficacy of your vitamin C serum is to look out for the PAO (period after opening) symbol on the outer packaging

2017;67:387.e385