An agonist is a natural ligand or a substance mimics the action of natural ligands that initiates responses when it binds to a specific receptor
Dina Peralta-Reich, M.D., a board-certified obesity medicine and pediatrics physician and the founder and director of New York Weight Wellness Medicine, a clinical practice that helps patients address eating disorders, weight maintenance, and issues related to overweight and obesity
[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Merza N, Saab O, Nawras Y, et al
Other GLP-1s have not listed dysesthesia as an adverse effect
Online platforms now make it easier to obtain these medications
Summary: Retatrutide commonly makes people feel reduced appetite and fullness after small meals, alongside gastrointestinal effects such as nausea, diarrhoea, and bloating, particularly during dose escalation