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Shared decision-making becomes especially important when patients are experiencing meaningful improvements in glycemic control or weight reduction

Drug Testing and Analysis

69 In comparison, newer oral small-molecule GLP-1 RAs, such as danuglipron and orforglipron, have demonstrated similar efficacy

While they may cause modest increases in heart rate (typically 2-4 beats per minute) and modest decreases in blood pressure, they do not significantly raise core body temperature or substantially accelerate metabolic rate

In both cases, you will use the vial before stability becomes a concern

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