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Skeletal muscle has a high metabolic demand
Side effects often temporarily worsened when the dose was uptitrated
Saxenda is a daily injection, while Mounjaro and Wegovy are given once a week
The most frequently reported side effects of injectable tirzepatide include: Nausea often the most common complaint, typically occurring within the first few weeks of treatment Diarrhoea loose or frequent bowel movements affecting a significant proportion of patients Vomiting may occur alongside nausea, particularly if dietary modifications are not implemented Decreased appetite whilst therapeutically beneficial for weight management, some patients find this uncomfortable Abdominal discomfort or pain ranging from mild bloating to cramping sensations Constipation paradoxically, some patients experience reduced bowel frequency Dyspepsia indigestion or upper abdominal discomfort These gastrointestinal effects result directly from the medication's mechanism of slowing gastric emptying and altering gut motility
Pinching the skin creates a fold that ensures subcutaneous rather than intramuscular injection
It supports cell migration and differentiation necessary for tissue repair
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