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GLP-1 medications slow gastric emptying, which often leads to nausea and vomiting, especially early in treatment

[DOI] [PMC free article] [PubMed] [Google Scholar] 100.Morroniside, a secoiridoid glycoside from Cornus officinalis, attenuates neuropathic pain by activation of spinal glucagon-like peptide-1 receptors

however it increases when used in conjunction with insulin or insulin secretagogues (Garber 2011)

Sloth B, Davidsen L, Holst JJ, Flint A, Astrup A

Theres also no set recommendation on what time of day works best

Individuals with a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should avoid GLP-1 receptor agonists