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In pancreatic cancer, the Kirsten rat sarcoma viral oncogene homolog (KRAS) gene reprograms glutamine metabolism by upregulating aspartate transaminase (GOT1) and repressing GLUD1 to increase the NADPH/NADP(+) ratio for stable redox capacity (Son et al., 2013)
Intramuscular injection Intramuscular injection delivers HCG into muscle tissue, typically the deltoid (upper arm) or the vastus lateralis (outer thigh)
Begin with 250mcg daily for the first week to assess tolerance
An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice
If remission is not achieved with topical therapy alone, oral 5-ASAs can be added in combination
Solvent-carrier risk: Vehicles such as DMSO are potent skin-penetration enhancers with their own irritation and contamination-shuttling risks
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