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Moreover, cyclosporin has been found to disrupt the pregnane X receptor (PXR) pathway, which regulates drug-metabolizing enzymes and transporters, leading to impaired bile acid metabolism and cholestasis (Shang et al

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The GLP-1RA drugs semaglutide and liraglutide, due to their longer half-lives, may have more prolonged effects in the CNS and regulate appetite metabolic processes (30)

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The degree of "success" correlates closely with degree of metabolic disease