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Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function

As demonstrated in a recent meta-analysis, SGLT-2i treatment is associated with increased plasma fasting glucagon levels in patients with diabetes compared with non-SGLT-2i treatments with a reduction of insulin and increased ketone body levels (91)

By these actions, the glucagon-like peptide 1 (GLP-1) assists in moderators of any sharp increases in blood glucose levels

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11-13 GLP-1 receptors are expressed in multiple tissues, therefore, GLP-1RAs have multiple mechanisms of action (Figure 2)

Genetic instruments were derived from cis-eQTLs for GLP-1R, and analyses were conducted using large-scale GWAS datasets