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doi: 10.1016/j.clinre.2016.12.007 7

30 overweight or obese (body mass index [BMI] 25.0 kg/m 2 ) patients aged from 2765 years in whom MetS was diagnosed according to the updated National Cholesterol Education Program/Adult treatment Panel III criteria for Asians were enrolled into the study

The cryo-EM maps allowed us to build an unambiguous model for most regions of the complexes except for the flexible -helical domain (AHD) of G and the stalk between transmembrane helice 1 (TM1) and extracellular domain (ECD), which were poorly resolved in most cryo-EM structures of GPCRG s complex (Supplementary Fig

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