PCD can be more severe at birth than CF due to the immediate failure of ciliary clearance, and so infants with PCD often present with more respiratory distress and develop bronchiectasis with recurrent infections earlier than those with CF (Mller et al., 2006
Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis
Unlike many conventional drugs that act broadly throughout the body, peptides can be engineered to target specific tissues or processes, maximizing their therapeutic potential
[DOI] [PubMed] [Google Scholar] 281.Janssens MY, Verovski VN, Van den Berge DL, Monsaert C, Storme GA
10.1016/j.jaut.2018.11.001 48 FengH.SchorppK.JinJ.YozwiakC
At the level of expression regulation, Pickarts transcriptomic studies indicate that the compound affects the expression of hundreds of genes related to tissue repair, antioxidant defense and anti-inflammation in profile analyses, it acted as a modulator shifting the expression pattern towards the repair profile (Pickart et al