Thyroid C-cell tumours have been observed in rodent studies, though no causal link has been established in humans
Cardiovascular effects Heart rate increased in a dose-dependent manner during the first 24 weeks of treatment, with the largest average increase being approximately 6.7 beats per minute at the 12 mg dose
Atrial fibrillation is a heart rhythm disorder where the upper chambers of the heart (the atria) beat irregularly and rapidly
Eligibility criteria Studies were included if they met the following criteria, according to the PICOS framework: Population Adults ( 18 years) only at high risk for cardiovascular disease (CVD) or with established CVD (coronary artery disease, heart failure, prior myocardial infarction, stroke)
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the path from rodent studies to validated human outcomes is long and uncertain
