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Uremic toxins such as indoxyl sulfate and p-cresyl sulfate, derived from microbial metabolism, impair kidney function and disrupt neurocognitive health via oxidative stress and neuroinflammation, highlighting the interconnectedness of these systems

They are also discreet, easy to transport and can be incorporated into a daily routine of a research subject more easily than other methods of peptide administration, as they dont require sterile environments or reconstitution

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At the same time, retatrutide is still being studied, so there isnt a finalized dosing guide yet

DOI:10.1007/s00203-024-04030-3 131